The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain | PLOS ONE
![Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements](https://c8.alamy.com/zooms/9/4cadf639fffb408ba2898fffe80e69cc/2gg0cpc.jpg)
Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements
![Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram](https://www.researchgate.net/publication/7845090/figure/fig1/AS:277751803203584@1443232598551/Structure-and-putative-protein-binding-properties-of-the-CAG-repeats-hairpins-A.png)
Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram
![Molecular Genesis Of Huntington's Disease, 3D Illustration. Expansion Of The CAG Trinucleotide Sequence In The Htt Gene Causes Production Of Mutated Huntingtin Protein Leading To Neurodegeneration Stock Photo, Picture And Royalty Free Molecular Genesis Of Huntington's Disease, 3D Illustration. Expansion Of The CAG Trinucleotide Sequence In The Htt Gene Causes Production Of Mutated Huntingtin Protein Leading To Neurodegeneration Stock Photo, Picture And Royalty Free](https://previews.123rf.com/images/drmicrobe/drmicrobe2105/drmicrobe210500214/171429573-molecular-genesis-of-huntington-s-disease-3d-illustration-expansion-of-the-cag-trinucleotide.jpg)
Molecular Genesis Of Huntington's Disease, 3D Illustration. Expansion Of The CAG Trinucleotide Sequence In The Htt Gene Causes Production Of Mutated Huntingtin Protein Leading To Neurodegeneration Stock Photo, Picture And Royalty Free
![Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/527571e7-f108-4b9a-b97f-6332eae501c9/fx1_lrg.jpg)
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids
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Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide: Molecular Therapy - Nucleic Acids
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Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein | Scientific Reports
![In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2405844021001936-gr1.jpg)
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect
![HIV drug could be repurposed to prevent toxic protein build-up in dementia and Huntington's disease, University of Cambridge research suggests HIV drug could be repurposed to prevent toxic protein build-up in dementia and Huntington's disease, University of Cambridge research suggests](https://www.cambridgeindependent.co.uk/_media/img/ELEALA1SOPTR6OH0KVR2.jpg)
HIV drug could be repurposed to prevent toxic protein build-up in dementia and Huntington's disease, University of Cambridge research suggests
![Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S089662732200006X-fx1.jpg)
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect
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A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease: Molecular Therapy - Nucleic Acids
![A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities: Molecular Therapy - Nucleic Acids A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/fc5144ac-0dd5-40d7-9cdf-e43e4538dbee/fx1_lrg.jpg)